Serrapeptase References

The Health-Care Survivor Provides More Than 100 Scientific References For Serrapeptase — The ‘Miracle’ Enzyme
  • Academy of Breastfeeding Medicine Protocol Committee, Berens P. ABM clinical protocol #20: Engorgement. Breastfeed Med. 2009 Jun;4(2):111-3. PubMed PMID: 19517578.
  • Al-Khateeb TH, Nusair Y. Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. Int J Oral Maxillofac Surg. 2008 Mar;37(3) 264-268. doi:10.1016/j.ijom.2007.11.011. PMID: 18272344.
  • Al-Khateeb TH, Nusair Y. Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. Int J Oral Maxillofac Surg. 2008 Mar;37(3):264-8. doi: 10.1016/j.ijom.2007.11.011. Epub 2008 Feb 12. PubMed PMID: 18272344.
  • Al-Khateeb, T.H. and Nusair, Y. “Effect of the Proteolytic Enzyme Serrapeptase on Swelling, Pain and Trismus After Surgical Extraction of Mandibular Third Molars.” International Journal of Oral and Maxillofacial Surgery, March 2008, Vol. 37, No. 3, pp. 264-8.
  • Alessandrini A, Ferrari D, Bastianon A, Maccagno A. [Granulated feprazone in acute inflammatory pathology of the bronchial tree. Study in comparison to a serratiopeptidase]. Clin Ter. 1985 May 31;113(4):275-80. Italian. PubMed PMID: 3893867.
  • Alherbish A, Charrois TL, Ackman ML, Tsuyuki RT, Ezekowitz JA. The prevalence of natural health product use in patients with acute cardiovascular disease. PLoS One. 2011;6(5) e19623. doi:10.1371/journal.pone.0019623. PMID: 21573067; PMCID: PMC3090400.
  • Aratani H, Kono S, Yamanaka Y. [Fundamental studies on the distribution of sulfobenzylpenicillin. Effect of serratiopeptidase (author’s transl)]. Jpn J Antibiot. 1974 Jun;27(3):271-8. Japanese. PubMed PMID: 4436946.
  • Aratani H, Tateishi H, Negita S. [Studies on in vivo activity of antibiotics in experimental pneumonia in rats. I. Combination of ciclacillin and serratiopeptidase (author’s transl)]. Jpn J Antibiot. 1979 Aug;32(8):806-11. Japanese. PubMed PMID: 490898.
  • Aratani H, Tateishi H, Negita S. [Studies on the distributions of antibiotics in the oral tissues: Experimental staphylococcal infection in rats, and effect of serratiopeptidase on the distributions of antibiotics (author’s transl)]. Jpn J Antibiot. 1980 May;33(5):623-35. Japanese. PubMed PMID: 7001087.
  • Artini M, Papa R, Scoarughi GL, Galano E, Barbato G, Pucci P, Selan L. Comparison of the action of different proteases on virulence properties related to the staphylococcal surface. J Appl Microbiol. 2013 Jan;114(1):266-77. doi: 10.1111/jam.12038. Epub 2012 Nov 19. PubMed PMID: 23057709.
  • Artini M, Scoarughi GL, Papa R, Cellini A, Carpentieri A, Pucci P, Amoresano A, Gazzola S, Cocconcelli PS, Selan L. A new anti-infective strategy to reduce adhesion-mediated virulence in Staphylococcus aureus affecting surface proteins. Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):661-72. PubMed PMID: 21978698.
  • Aso T. et al. Breast engorgement and its treatment: Clinical effects of (Serrapeptase) an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynaecology (Japanese). 1981:33:371-9.
  • Badhe RV, Nanda RK, Kulkarni MB, Bhujbal MN, Patil PS, Badhe SR. Media optimization studies for Serratiopeptidase production from Serratia marcescens ATCC 13880. Hindustan Antibiot Bull. 2009;51(1-4):17-23. PubMed PMID: 21268555.
  • Balaji SM. Use of recombinant human Bone Morphogenetic Protein (rhBMP-2) in reconstruction of maxillary alveolar clefts. J Maxillofac Oral Surg. 2009 Sep;8(3):211-7. doi: 10.1007/s12663-009-0052-5. Epub 2009 Nov 21. PubMed PMID: 23139510; PubMed Central PMCID: PMC3454232.
  • Balliett M, Burke JR. Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients participating in a low-energy dietary intervention. J Chiropr Med. 2013 Mar;12(1) 3-14. doi:10.1016/j.jcm.2012.11.003. PMID: 23997718; PMCID: PMC3610945.
  • Bhagat S, Agarwal M, Roy V. Serratiopeptidase: a systematic review of the existing evidence. Int J Surg. 2013;11(3):209-17. doi: 10.1016/j.ijsu.2013.01.010. Epub 2013 Feb 1. Review. PubMed PMID: 23380245.
  • Bracale G, Selvetella L. [Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase]. Minerva Cardioangiol. 1996 Oct;44(10):515-24. Italian. PubMed PMID: 9091835.
  • Braga, P.C. et al. Effects of Serrapeptase on muco-ciliary clearance in patients with chronic bronchitis. Curr. Ther. Res. 29(5): 738-744,1981.
  • Bruno E, Porcellini A, Farronato GP. [Clinical study of a new oral anti-inflammatory: Zami 642]. Dent Cadmos. 1986 Oct 15;54(15):81-3. Italian. PubMed PMID: 3552763.
  • Bucci E, Mignogna MD, Bucci P. [Aulin: a new modern drug in the treatment of inflammation in dentistry]. Minerva Stomatol. 1987 Jan-Feb;36(1-2):101-3. Italian. PubMed PMID: 3553887.
  • Bucci E, Signoriello G, Perrino IF, Bucci P. [Clinico-pharmacological comparison between between enzyme-type anti-inflammatory agents postoperatively in oral surgery]. Minerva Stomatol. 1986 May;35(5):503-6. Italian. PubMed PMID: 3526117.
  • Caroppo E, Niederberger C, Iacovazzi PA, Correale M, D’Amato G. Detection of 90K/MAC-2BP in the seminal plasma of infertile males with accessory gland infection and the autoimmune pathogenetic hypothesis. J Androl. 2006 Nov-Dec;27(6):780-4. Epub 2006 Jul 12. PubMed PMID: 16837737.
  • Carratu, L. et al. Physio-chemical and rheological research on mucolytic activity of Serrapeptase in chronic broncho-pneumopathies. Curr. Ther. Res. 28(6): 937-951. 1980.
  • Chappi D M, Suresh KV, Patil MR, Desai R, Tauro DP, Bharani K N S S, Parkar MI, Babaji HV. Comparison of clinical efficacy of methylprednisolone and serratiopeptidase for reduction of postoperative sequelae after lower third molar surgery. J Clin Exp Dent. 2015 Apr 1;7(2):e197-202. doi: 10.4317/jced.51868. eCollection 2015 Apr. PubMed PMID: 26155332; PubMed Central PMCID: PMC4483323.
  • Chopra D, Rehan HS, Mehra P, Kakkar AK. A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. Int J Oral Maxillofac Surg. 2009 Apr;38(4):350-5. doi: 10.1016/j.ijom.2008.12.013. Epub 2009 Jan 24. PubMed PMID: 19168326.
  • Dallas P, Rekkas D, Choulis NH. HPLC determination of serratiopeptidase in biological fluids. Pharmazie. 1989 Apr;44(4):297. PubMed PMID: 2672036.
  • Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joints in treatment with Serrapeptase a prospective study (German). FortschrMed. 1989; 107(4): 67-8, 71-2.
  • Esch PM, Gerngross H, Fabian A. [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase– a prospective study] Fortschr Med. 1989 Feb;107(4) 67-8, 71-2. PMID: 2647603.
  • Esch PM, Gerngross H, Fabian A. [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase– a prospective study]. Fortschr Med. 1989 Feb 10;107(4):67-8, 71-2. German. PubMed PMID: 2647603.
  • Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase and nattokinase intervention for relieving Alzheimer’s disease pathophysiology in rat model. Hum Exp Toxicol. 2013 Jul;32(7) 721-735. doi:10.1177/0960327112467040. PMID: 23821590.
  • Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase and nattokinase intervention for relieving Alzheimer’s disease pathophysiology in rat model. Hum Exp Toxicol. 2013 Jul;32(7):721-35. doi: 10.1177/0960327112467040. PubMed PMID: 23821590.
  • Fujitani, T. et al. Effect of anti-inflammatory agent on transfer of antibiotics to the maxillary sinus mucosa in chronic sinusitis. Otorhinolaryngol. Clin. North Am. 66:557-565. 1976.
  • Furlong J, Rynders CA, Sutherlin M, Patrie J, Katch FI, Hertel J, Weltman A. Effect of an herbal/botanical supplement on strength, balance, and muscle function following 12-weeks of resistance training: a placebo controlled study. J Int Soc Sports Nutr. 2014;11 23. doi:10.1186/1550-2783-11-23. PMID: 24910543; PMCID: PMC4047772.
  • Harad, Y. Clinical efficacy of Serrapeptase on buccal swelling after radical operation for chronic sinusitis. Igaku Ayumi 123:768-778.1982.
  • Hirahara K, Saitoh T, Terada I, Uno K, Nagai A, Kioi S, Arakawa M. [A case of pneumonitis due to serrapeptase] Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Oct;27(10) 1231-1236. PMID: 2693781.
  • Hirahara K, Saitoh T, Terada I, Uno K, Nagai A, Kioi S, Arakawa M. [A case of pneumonitis due to serrapeptase]. Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Oct;27(10):1231-6. Japanese. PubMed PMID: 2693781.
  • Ijitsu T, Yonezawa K, Ueno M. [Improved analysis of serrapeptase by high performance steric exclusion chromatography (SEC). I] Yakugaku Zasshi. 1986 Jan;106(1) 95-98. PMID: 3517293.
  • Ijitsu T, Yonezawa K, Ueno M. [Improved analysis of serrapeptase by high performance steric exclusion chromatography (SEC). I]. Yakugaku Zasshi. 1986 Jan;106(1):95-8. Japanese. PubMed PMID: 3517293.
  • Ishihara Y, Kitamura S, Takaku F. [Experimental studies on distribution of cefotiam, a new beta-lactam antibiotic, in the lung and trachea of rabbits. II. Combined effects with serratiopeptidase]. Jpn J Antibiot. 1983 Oct;36(10):2665-70. Japanese. PubMed PMID: 6325734.
  • Jadav SP, Patel NH, Shah TG, Gajera MV, Trivedi HR, Shah BK. Comparison of anti-inflammatory activity of serratiopeptidase and diclofenac in albino rats. J Pharmacol Pharmacother. 2010 Jul;1(2):116-7. doi: 10.4103/0976-500X.72362. PubMed PMID: 21350623; PubMed Central PMCID: PMC3043339.
  • Jadav, S.P., et. al. “Comparison of Anti-Inflammatory Activity of Serratiopeptidase and Diclofenac in Albino Rats.” Journal of Pharmacology and Pharmacotherapeutics, 2010, Vol. 1, No. 2, pp. 116-17.
  • Joshi KK, Nerurkar RP. Anti-inflammatory effect of the serratiopeptidase–rationale or fashionable: a study in rat paw oedema model induced by the carrageenan. Indian J Physiol Pharmacol. 2012 Oct-Dec;56(4):367-74. PubMed PMID: 23781657.
  • Kai N, Shirai R, Hirata N, Iwata A, Umeki K, Ishii H, Kishi K, Tokimatsu I, Hiramatsu K, Kadota J. [A case of eosinophilic pneumonia due to Nicolase (serrapeptase) after recovery from acute eosinophilic pneumonia]. Nihon Kokyuki Gakkai Zasshi. 2009 Mar;47(3) 254-258. PMID: 19348276.
  • Kai N, Shirai R, Hirata N, Iwata A, Umeki K, Ishii H, Kishi K, Tokimatsu I, Hiramatsu K, Kadota J. [A case of eosinophilic pneumonia due to Nicolase (serrapeptase) after recovery from acute eosinophilic pneumonia]. Nihon Kokyuki Gakkai Zasshi. 2009 Mar;47(3):254-8. Japanese. PubMed PMID: 19348276.
  • Kakinumu, A. et al. Regression of fibrinolysis in scalded rats by administration of Serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.
  • Kasé Y, Seo H, Oyama Y, Sakata M, Tomoda K, Takahama K, Hitoshi T, Okano Y, Miyata T. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, serratiopeptidase and seaprose. Arzneimittelforschung. 1982;32(4):374-8. PubMed PMID: 7049188.
  • Kase, Y. et al. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, Serrapeptase and seaprose. Arzneimittelforschung 32:374-378,1982.
  • Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb;30(1) 48-54. PMID: 2688125.
  • Kee WH, Tan SL, Lee V, Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. Singapore Med J. 1989 Feb;30(1):48-54. PubMed PMID: 2688125.
  • Kee WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase: a randomised double blind controlled trial. Singapore Med J. 1989:30(1): 48-54.
  • Koga Y, Mishima Y, Saho M, Ito A, Ito T, Hiraki T, Ushijima K. A case of serious laryngeal edema unpredictably detected during laryngoscopy for orotracheal intubation following induction of anesthesia. J Anesth. 2011 Aug;25(4) 589-591. doi:10.1007/s00540-011-1150-3. PMID: 21533587; PMCID: PMC3152709.
  • Kotb E. The biotechnological potential of fibrinolytic enzymes in the dissolution of endogenous blood thrombi. Biotechnol Prog. 2014 May-Jun;30(3) 656-672. doi:10.1002/btpr.1918. PMID: 24799449.
  • Kotb E. The biotechnological potential of fibrinolytic enzymes in the dissolution of endogenous blood thrombi. Biotechnol Prog. 2014 May-Jun;30(3):656-72. doi: 10.1002/btpr.1918. Epub 2014 May 7. Review. PubMed PMID: 24799449.
  • Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al. Augmentation by Serrapeptase of tissue permeation by cefotiam (Japanese). Jpn JAntibiot. 1986; 39(3): 761-71.
  • Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T. [Augmentation by serrapeptase of tissue permeation by cefotiam] Jpn J Antibiot. 1986 Mar;39(3) 761-771. PMID: 3525882.
  • Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al. [Augmentation by serrapeptase of tissue permeation by cefotiam]. Jpn J Antibiot. 1986 Mar;39(3):761-71. Japanese. PubMed PMID: 3525882.
  • Kumar S, Jana AK, Dhamija I, Maiti M. Chitosan-assisted immobilization of serratiopeptidase on magnetic nanoparticles, characterization and its target delivery. J Drug Target. 2014 Feb;22(2):123-37. doi: 10.3109/1061186X.2013.844157. Epub 2013 Oct 23. PubMed PMID: 24148085.
  • Kumar S, Jana AK, Dhamija I, Singla Y, Maiti M. Preparation, characterization and targeted delivery of serratiopeptidase immobilized on amino-functionalized magnetic nanoparticles. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):413-26. doi: 10.1016/j.ejpb.2013.06.019. Epub 2013 Jul 10. PubMed PMID: 23851102.
  • Kumari N, Pathak K. Dual controlled release, in situ gelling periodontal sol of metronidazole benzoate and serratiopeptidase: statistical optimization and mechanistic evaluation. Curr Drug Deliv. 2012 Jan;9(1):74-84. PubMed PMID: 22023207.
  • KV S, Devi GS, Mathew ST. Liposomal formulations of serratiopeptidase: in vitro studies using PAMPA and Caco-2 models. Mol Pharm. 2008 Jan-Feb;5(1):92-7. Epub 2007 Dec 27. PubMed PMID: 18159928.
  • Larrey D, Vial T, Micaleff A, Babany G, Morichau-Beauchant M, Michel H, Benhamou JP. Hepatitis associated with amoxycillin-clavulanic acid combination report of 15 cases. Gut. 1992 Mar;33(3) 368-371. doi:10.1136/gut.33.3.368. PMID: 1568657; PMCID: PMC1373830.
  • Lee HS, Majima Y, Sakakura Y, Kim BW. A technique for quantitative cytology of nasal secretions. Eur Arch Otorhinolaryngol. 1991;248(7):406-8. PubMed PMID: 1747249.
  • Longhi C, Scoarughi GL, Poggiali F, Cellini A, Carpentieri A, Seganti L, Pucci P, Amoresano A, Cocconcelli PS, Artini M, Costerton JW, Selan L. Protease treatment affects both invasion ability and biofilm formation in Listeria monocytogenes. Microb Pathog. 2008 Jul;45(1):45-52. doi: 10.1016/j.micpath.2008.01.007. Epub 2008 Mar 25. PubMed PMID: 18479885.
  • Longhi, C., et. al. “Protease Treatment Affects Both Invasion Ability and Biofilm Formation in Listeria Monocytogenes.” Microbial Pathogenesis, July 2008, Vol. 45, No. 1, pp. 45-52.
  • Maheshwari M, Miglani G, Mali A, Paradkar A, Yamamura S, Kadam S. Development of tetracycline-serratiopeptidase-containing periodontal gel: formulation and preliminary clinical study. AAPS PharmSciTech. 2006 Sep 15;7(3):76. PubMed PMID: 17025256; PubMed Central PMCID: PMC2750518.
  • Majima Y, Hirata K, Takeuchi K, Hattori M, Sakakura Y. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am Rev Respir Dis. 1990 Jan;141(1):79-83. PubMed PMID: 2404442.
  • Majima Y, Inagaki M, Hirata K, Takeuchi K, Morishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. PubMed PMID: 3279939.
  • Majima Y, lnagaki M, Hirata K. Takeuchi K, M orishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988; 244(6):355-9.
  • Majima. Y. et al. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am. Rev. Respit. Dis. 141:79-83.1990.
  • Mali N, Wavikar P, Vavia P. Serratiopeptidase loaded chitosan nanoparticles by polyelectrolyte complexation: in vitro and in vivo evaluation. AAPS PharmSciTech. 2015 Feb;16(1):59-66. doi: 10.1208/s12249-014-0201-0. Epub 2014 Aug 30. PubMed PMID: 25171974; PubMed Central PMCID: PMC4309803.
  • Malshe PC. A preliminary trial of serratiopeptidase in patients with carpal tunnel Syndrome. J Assoc Physicians India. 2000 Nov;48(11):1130. PubMed PMID: 11310402.
  • Malshe PC. Orally administered serratiopeptidase: can it work? J Assoc Physicians India. 1998 May;46(5):492. PubMed PMID: 11273304.
  • Mangesi L, Dowswell T. Treatments for breast engorgement during lactation. Cochrane Database Syst Rev. 2010 CD006946. doi:10.1002/14651858.cd006946.pub2. PMID: 20824853; PMCID: PMC4161489.
  • Marly, M. Enzymotherapie anti-inflammatoire a l’aide de la Serrapeptase: resultats cliniques en traumatologie et en ORL. C RTherapeut. 3:9-19,1985.
  • Marriott, C. Modification of the rheoloaical properties of mucus by drugs. Adv. Exp. Med. Biol. 144^75-84, 1982.
  • Matsudo, A. et at. Effect of Serrapeptase on inflammatory oedema following operation for thyropid disease. Med. Consult. New Remedy 18:171-175, 1981.
  • Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990 Sep-Oct;18(5):379-88. PubMed PMID: 2257960.
  • Mazzonie, A. et al. Evaluation of Serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind randomised trial versus placebo. J. Int. Med. Res. 18(5): 379-388,1990.
  • Mazzonie, A. et al. Evaluation of Serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind randomised trial versus placebo. J. int. Med. Res. 18(5): 379-388,1990.
  • Mecikoglu M, Saygi B, Yildirim Y, Karadag-Saygi E, Ramadan SS, Esemenli T. The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection. J Bone Joint Surg Am. 2006 Jun;88(6):1208-14. PubMed PMID: 16757752.
  • Merten HA, Müller K, Drubel F, Halling F. [Volumetric verification of edema protection with Serrapeptase after third molar osteotomy] Dtsch Z Mund Kiefer Gesichtschir. 1991 Jul-Aug;15(4) 302-305. PMID: 1816962.
  • Merten HA, Müller K, Drubel F, Halling F. [Volumetric verification of edema protection with Serrapeptase after third molar osteotomy]. Dtsch Z Mund Kiefer Gesichtschir. 1991 Jul-Aug;15(4):302-5. German. PubMed PMID: 1816962.
  • Miyata, K. Intestinal absorption of Serrapeptase. J ApplBiochem. 1980:2:111-16.
  • Mizukoshi, D. et al. A double blind clinical study of Serrapeptase in the treatment of chronic sinusitis. Igaku Ayrni 109:50-62.1979.
  • Modabber A, Rana M, Ghassemi A, Gerressen M, Gellrich NC, Hölzle F, Rana M. Three-dimensional evaluation of postoperative swelling in treatment of zygomatic bone fractures using two different cooling therapy methods: a randomized, observer-blind, prospective study. Trials. 2013;14 238. doi:10.1186/1745-6215-14-238. PMID: 23895539; PMCID: PMC3729713.
  • Moitra S, Sen S, Banerjee I, Das P, Tripathi SK. Diclofenac-serratiopeptidase combination induced stevens – johnson syndrome – a rare case report with review of literature. J Clin Diagn Res. 2014 Jul;8(7):YD08-11. doi: 10.7860/JCDR/2014/9509.4610. Epub 2014 Jul 20. PubMed PMID: 25177625; PubMed Central PMCID: PMC4149131.
  • Moriya N, Nakata M, Nakamura M, Takaoka M, Iwasa S, Kato K, Kakinuma A. Intestinal absorption of serrapeptase (TSP) in rats. Biotechnol Appl Biochem. 1994 Aug;20 ( Pt 1) 101-108. PMID: 7917060.
  • Moriya N, Nakata M, Nakamura M, Takaoka M, Iwasa S, Kato K, Kakinuma A. Intestinal absorption of serrapeptase (TSP) in rats. Biotechnol Appl Biochem. 1994 Aug;20 ( Pt 1):101-8. PubMed PMID: 7917060.
  • Murugesan K, Sreekumar K, Sabapathy B. Comparison of the roles of serratiopeptidase and dexamethasone in the control of inflammation and trismus following impacted third molar surgery. Indian J Dent Res. 2012 Nov-Dec;23(6):709-13. doi: 10.4103/0970-9290.111243. PubMed PMID: 23649050.
  • Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology. 2003 Sep;8(3) 316-320. doi:10.1046/j.1440-1843.2003.00482.x. PMID: 12911824.
  • Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology. 2003 Sep;8(3):316-20. PubMed PMID: 12911824.
  • Nakamura, S., et. al. “Effect of the Proteolytic Enzyme Serrapeptase in Patients with Chronic Airway Disease.” Respirology, September 2003, Vol. 8, No. 3, pp. 316-20.
  • National Institute of Neurological Disorders and Stroke: “Study Ties Cerebral Palsy to Inflammation and Blood-Clotting Abnormalities”
  • Nirale NM, Menon MD. Topical formulations of serratiopeptidase: development and pharmacodynamic evaluation. Indian J Pharm Sci. 2010 Jan;72(1):65-71. doi: 10.4103/0250-474X.62246. PubMed PMID: 20582192; PubMed Central PMCID: PMC2883229.
  • Odagiri, J. et al. Clinical applications of Serrapeptase in sinusitis. Med. Consult. New Remedy 6:201-209, 1979.
  • Okumura H, Watanabe R, Kotoura Y, Nakane Y, Tangiku O. [Effects of a proteolytic-enzyme preparation used concomitantly with an antibiotic in osteoarticular infections (author’s transl)]. Jpn J Antibiot. 1977 Mar;30(3):223-7. Japanese. PubMed PMID: 853579.
  • Ovartlarnporn B, Kulwichit W, Hiranniramol S. Medication-induced esophageal injury: report of 17 cases with endoscopic documentation. Am J Gastroenterol. 1991 Jun;86(6):748-50. PubMed PMID: 2038999.
  • Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 1999 Dec;47(12):1170-2. PubMed PMID: 11225219.
  • Panagariya A., Sharma, A.K. “A Preliminary Trial of Serrapeptase in Patients with Carpal Tunnel Syndrome.” Journal of the Association of Physicians of India, December 1999, Vol. 47, No. 12, pp. 1170-2.
  • Pansuriya R, Singhal R. Effects of dissolved oxygen and agitation on production of serratiopeptidase by Serratia marcescens NRRL B-23112 in stirred tank bioreactor and its kinetic modeling. J Microbiol Biotechnol. 2011 Apr;21(4):430-7. PubMed PMID: 21532328.